winter season fruit a large number of market, sweet and sour, delicious, nutritious grapefruit won the love of the majority of consumers. However, recently, articles such as “Grapefruit eating like this is very dangerous, or even sudden death” and “be careful, there is a kind of grapefruit that is very dangerous, even sudden death” and other articles have been circulated on the Internet. The article said that “eating grapefruit after taking medicine will be very dangerous, even sudden death may occur.”. China’s food official account of the official WeChat public of the State Food and drug administration has been dispelled.

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and “Chinese food and Drug News” point out three “truths”: first, only grapefruit can cause adverse reactions when taken with some drugs; secondly, when the consumption of grapefruit and drugs reaches the reaction dose, the corresponding toxic reaction will be caused; otherwise, there will be no effect; Thirdly, furanocoumarins in grapefruit are mainly confined to the small intestine and interact with drugs, which are usually affected by oral drugs.

Grapefruit is also known as grapefruit or Huyou. “China food drug” quoted the introduction of the WeChat public “popular science China” official account, pointing out that strictly speaking from the scientific level, “eating grapefruit is equal to taking poison” after taking medicine is not accurate. According to the analysis, only grapefruit can cause adverse reactions when taking with some drugs; moreover, the relationship between drug reaction and experiment should be considered. When the consumption of grapefruit and drug reaches the reaction dose, the corresponding toxic reaction will be caused, otherwise, there will be no effect.

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in addition, the flesh of grapefruit contains furanocoumarins, which can inhibit the activity of CYP3A4, a drug metabolizing enzyme in human intestine, thus reducing the decomposition of drugs and increasing the drug concentration in blood. According to Ruan Guangfeng, director of the science and Technology Department of the food and nutrition information exchange center, grapefruit affects more drugs. In some cases, it can reduce the drug discharge and increase the efficacy; sometimes it can interfere with the drug transport and reduce the efficacy. Zhou Yonggang, director of the pharmacy department of the 81st Hospital of the Chinese PLA, stressed that only grapefruit had a greater impact on the drug, while other grapefruit varieties would not have such a significant impact on drug absorption.

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and the furanocoumarins in grapefruit are mainly confined to the small intestine and interact with drugs, which are usually affected by oral drugs. Up to now, no adverse reactions have been found between grapefruit and drugs under intravenous administration.

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in addition, grapefruit can not eat the same drug: lipid lowering drugs (such as statins), dihydropyridine antihypertensive drugs (such as nifedipine), some sedative and sleeping drugs (such as midazolam), immunosuppressants (such as cyclosporine), some antiepileptic drugs (such as carbamazepine), warfarin, etc. At the same time, according to the literature reports, the antihypertensive drugs that have obvious interaction with grapefruit juice are mainly dihydropyridine calcium anticoagulants (commonly known as “dipine drugs”), such as felodipine, nifedipine, etc.

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and “Chinese food and Drug News” finally said that the “sudden death of grapefruit and drugs” mentioned in the online article was not true, only that grapefruit might affect the drug efficacy. It is suggested that the patients who take the above drugs orally should eat grapefruit carefully.

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