vitamin C is mainly used for the treatment of vitamin C deficiency disease and vitamin C supplement treatment in clinical practice. There are two dosage forms of injection and oral preparation. In clinical application, it is often used in combination with other drugs to achieve therapeutic effect. Therefore, we have to pay attention to the combination of vitamin C and drugs.

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compound Aucklandiae and magnesium and vitamin C

,

compound Aucklandiae and magnesium are a kind of gastric mucosal protective agent, which will interfere with the absorption and clearance of vitamins and affect the therapeutic effect of vitamins. Therefore, it is necessary to avoid the combination of compound Aucklandia and vitamin C.

sulfonamides and vitamin C

such as sulfadiazine, sulfamethoxazole and other sulfonamides combined with vitamin C can increase the excretion of vitamin C and reduce the therapeutic effect; On the other hand, if the two drugs are used for a long time, a large dose of vitamin C will promote the crystallization of sulfonamides in the kidney, so the combination of the two drugs should be avoided.

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sodium bicarbonate and vitamin C

and

sodium bicarbonate are alkaline, and vitamin C is acidic. The combination of the two drugs will cause neutralization reaction and reduce the efficacy of the two drugs. Therefore, the combination of the two drugs should be avoided. Erythromycin of

and erythromycin of vitamin C

belong to macrolide antibiotics. In alkaline environment, their antibacterial effect will increase with the increase of pH value, while vitamin C is acidic. After the combination of erythromycin and vitamin C in acidic environment, erythromycin will be destroyed by a large number of decomposition, affecting its antibacterial effect, so erythromycin should not be combined with vitamin C. Vitamin B of

and

and vitamin C

and

are amphoteric compounds, and their oxidizability is greater than that of reduction. Vitamin C has a strong reducibility. When vitamin C is combined with vitamin B, redox reaction will occur. Vitamin C will cause vitamin B to be destroyed into reducing vitamin B and lose the curative effect. Therefore, vitamin B should not be combined with vitamin C.

vitamin B12 and vitamin C

taking large doses of vitamin C will damage the synthesis of vitamin B12 in the liver. Therefore, vitamin B12 deficient people should not take a large amount of vitamin C to avoid anemia.

vitamin K and vitamin C

vitamin C have strong reducibility, while vitamin K has certain oxidation. After the two drugs are combined, redox reaction will occur, vitamin K is easy to lead to failure, so the two drugs should not be combined.

calcium and vitamin C

taking large doses of vitamin C will promote calcium crystallization in the kidney, so vitamin C should not be combined with calcium.

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ciprofloxacin and vitamin C

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vitamin C can reduce the oral bioavailability of ciprofloxacin, reduce the absorption of ciprofloxacin, and thus reduce its curative effect. Therefore, the dosage of ciprofloxacin should be adjusted or ofloxacin should be used in combination.

deferoxamine and vitamin C

vitamin C can promote the iron complexation of deferoxamine, increase urinary iron excretion, and reduce its curative effect. Therefore, the dosage of deferoxamine can be appropriately increased during the combination of the two drugs. After taking

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propranolol and vitamin C

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propranolol and vitamin C at the same time, vitamin C can significantly reduce the average peak plasma concentration of propranolol and the area under the drug time curve, which affects the therapeutic effect of propranolol. Therefore, it is suggested to stagger the administration time of propranolol and vitamin C, or appropriately increase the dosage of propranolol according to the needs of patients.

methacholine and vitamin C

methacholine are m-choline receptor agonists, which can increase bronchial secretion by constricting bronchial smooth muscle. However, after combined with vitamin C, vitamin C affects the metabolism of arachidonic acid and interferes with the production of prostaglandins, which can reduce the airway reaction caused by methacholine. Therefore, it is necessary to increase the dosage of methacholine during the combination of the two drugs to avoid affecting the therapeutic effect.

ferrous fumarate and vitamin C

ferrous fumarate combined with vitamin C, vitamin C can promote the absorption of ferrous fumarate, but it will also increase the incidence of gastrointestinal reactions. Therefore, it is necessary to pay close attention to the occurrence of gastrointestinal reactions during the combination of the two drugs, and timely reduce the dosage if necessary. The single oral bioavailability of ethinylestradiol and vitamin C can be increased to 60% – 70% by oral administration of

,

and vitamin C

and

. Therefore, the dosage adjustment should be paid attention to when the two drugs are combined.

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anticoagulant drugs and vitamin C

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oral large doses of vitamin C can interfere with the anticoagulant effect of heparin, warfarin sodium and other drugs, shorten the prothrombin time. Therefore, the dosage of vitamin C should be adjusted at any time according to the anticoagulant effect during the combined use.

acetylcysteine and vitamin C

vitamin C are acid drugs, and their curative effect will be reduced when combined with acetylcysteine. Therefore, we should pay close attention to the therapeutic effect of acetylcysteine during the combined use, and adjust the dosage or replace other drugs for symptomatic treatment if necessary.

folic acid and vitamin C

vitamin C are acid drugs. When taken with folic acid at the same time, vitamin C can inhibit the absorption of folic acid in the gastrointestinal tract, and promote the rapid decomposition of folic acid in acidic environment, which leads to the decrease of folic acid efficacy. Therefore, in the clinical application of anemia treatment, it is recommended that the two drugs should be taken at an interval of 1 hour. Dyclonine and vitamin C

,

and

and

will play a role in wound healing after crushing vitamin C tablets. Dyclonine has a certain analgesic effect. However, the dissociation value of Dyclonine will be affected due to the difference of pH value after the combination of Dyclonine and vitamin C

and

. Therefore, it is not recommended to combine the two drugs.

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tetracycline antibiotics and vitamin C “KD”The combination of tetracycline antibiotics such as tetracycline, oxytetracycline and chlortetracycline with vitamin C can increase the excretion of vitamin C. Therefore, the dosage of vitamin C should be appropriately increased during the combination of the two drugs.

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aspirin and vitamin C

Salicylic acid contained in

aspirin will produce salicylate after metabolism by liver drug enzymes. These salicylates are mainly excreted through the kidney, and the excretion amount is easily affected by the pH value of urine. Among them, the excretion rate of salicylate in acidic urine is less than 5%, and vitamin C is acidifying urine. Therefore, aspirin combined with vitamin C will lead to salicylate It is easy to cause salicylate poisoning. Therefore, aspirin and vitamin C should not be combined.

barbiturates and vitamin C

phenobarbital, barbital, pentobarbital and other barbital drugs will increase the excretion of vitamin C after combined with vitamin C. Therefore, the use dose of vitamin C should be appropriately supplemented in long-term application.

theophylline drugs and vitamin C

vitamin C can reduce the oral absorption rate of theophylline drugs and weaken its antiasthmatic effect. Therefore, if theophylline drugs are not well absorbed when taking vitamin C and theophylline drugs at the same time, quick absorption tablets or liquid preparations should be used instead, so as not to affect the therapeutic effect.

perphenazine and vitamin C

perphenazine are psychoactive drugs. When combined with vitamin C, they can reduce the content of vitamin C in the body. In addition, after the two drugs are taken orally at the same time, vitamin C will reduce the effectiveness of perphenazine and weaken the antipsychotic effect of perphenazine.

phenytoin sodium and vitamin C

phenytoin sodium aqueous solution are alkaline, phenytoin precipitation can be precipitated in acidic environment, but vitamin C injection is acidic. If the two injection preparations are injected together, white precipitate will be precipitated, so the injection preparation of the two drugs should not be compatible. In addition, for the oral preparations of the two drugs, vitamin C is easy to hinder the absorption of phenytoin sodium in vivo after the combination of vitamin C oral preparation and phenytoin sodium oral preparation in vivo, so as to reduce the bioavailability of phenytoin sodium and weaken its curative effect. Therefore, if the oral preparation needs to be combined, the blood concentration of phenytoin should be closely monitored and phenytoin sodium should be adjusted in time The dosage of the drug. When mitomycin

and vitamin C

are given intravenously at the same time, vitamin C can reduce the therapeutic effect of mitomycin C, so the two drugs should not be used in combination.

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metronidazole and vitamin C

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Metronidazole Injection and vitamin C injection will appear discoloration after intravenous drip, the color of the solution will become darker, and the content of metronidazole in the mixture will be significantly reduced. However, the color of Metronidazole Injection with high concentration was not significantly changed after being diluted with vitamin C injection for 24 hours. However, for the sake of safety, it is suggested that the two drugs should be administered separately.

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norfloxacin and vitamin C

and

norfloxacin injection have a certain degree of oxidation, while vitamin C has a strong reducibility. After intravenous drip of the two drugs at the same time, redox reaction will occur, and incompatible particles will be precipitated, which will increase the incidence of adverse reactions.

levodopa + vitamin C

vitamin C can interfere with the absorption of levodopa in the body and reduce the therapeutic effect of levodopa. Therefore, when the two drugs are combined, the treatment dose of levodopa should be appropriately increased. It can be seen that vitamin C can not be used if you want to use it. Improper use of vitamin C will not enhance the therapeutic effect, but will bring adverse reactions or reduce the therapeutic effect. Therefore, we should correctly understand vitamin C and scientifically supplement vitamin C. under normal circumstances, the dosage of vitamin C supplement for adults and early pregnant women is 100mg / D, and the dosage of vitamin C supplement for women in the second and third trimester of pregnancy and lactation women is 130mg / d. vitamin C can also be appropriately supplemented when you have a cold, but it is not suitable to take it for a long time, generally 3-5 days is appropriate.

and

should not only pay attention to the contraindications of vitamin C oral preparation, but also pay attention to the incompatibility of its injection preparation. Because of its strong reducibility and unstable nature, vitamin C is easy to decompose when exposed to light. Therefore, it should be kept away from light and intravenous drip is recommended.

and

vitamin C seems to be common drugs, and there are a lot of incompatibility that need to be paid attention to in clinical application, so as to achieve safe, effective and reasonable use. The above content of

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